Our results suggest that TARE drives constitute promising candidates for the development of effective, flexible, and regionally confinable drives for population modification. This drive was able to spread through a large cage population in just six generations following introduction at 24% frequency without any apparent evolution of resistance. We demonstrate a TARE drive in Drosophila with 88-95% transmission by female heterozygotes. Modeling shows that such drives will have threshold-dependent invasion dynamics, spreading only when introduced above a fitness-dependent frequency.

It functions by disrupting a target gene, forming recessive lethal alleles, while rescuing drive-carrying individuals with a recoded version of the target. Here, we introduce the Toxin-Antidote Recessive Embryo (TARE) drive. In addition, they are expected to be highly invasive. However, such drives face a major obstacle in the form of resistance against the drive.

Note that only one dose of the antidote is necessary, so the player only needs to manufacture it if the first dose is misplaced or destroyed.Engineered gene drives based on a homing mechanism could rapidly spread genetic alterations through a population. The recipe for the Kharaa Antidote will be unlocked when the player picks it up in the Spy Pengling cave. Also, even if Al-An has already left the protagonist's body (and is currently on the other end of the map), his voice will still be heard when the antidote is injected. Injecting the antidote is not necessary to complete the main quest and finish the game (in fact, Al-An won't even mention it and will gladly leave the planet before the antidote is injected, despite stating that he was on a mission to eliminate the bacteria). Although the leviathan is frozen (and confirmed to be dead), and therefore has no circulation, injecting a single pustule will cause all the others to disappear as well. Doing so will cause the pustules on the skin to dissipate, visually showing that the bacterium has been killed. The antidote can be used to decontaminate the Frozen Leviathan by loading it into the injection machine found near the creature's head and then using the nearby screen. It can be found in a Spy Pengling cave in the Glacial Basin, where it was hidden by Sam Ayou. The Antidote is an item that can be used to cure Kharaa.

What is antidote